Part of State Highway 1 was closed, and two people were seriously injured after a "serious" single-vehicle crash in Clutha, Otago.
Police were called to the scene near Webb Road on the Waipahi Highway/SH1 at around 12pm Saturday.
Hato Hone St John said three patients were transferred to nearby hospitals.
"Our crews assessed and treated two patients who were airlifted to Dunedin hospital in a serious condition and one patient who was transported by road to Kew hospital in a moderate condition," it said.
Two helicopters, an ambulance, two first response units, one rapid response unit and a manager reported to the crash site.
The road was blocked while emergency services attended the scene. Motorists were advised to avoid the area if possible and expect delays.
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