Serena Williams set up a third-round showdown at the US Open against her older sister by hitting 13 aces and overwhelming 101st-ranked Carina Witthoeft of Germany 6-2, 6-2 in a little more than an hour today.
This Williams vs. Williams matchup will be the earliest they've faced each other at a Grand Slam tournament in 20 years.
Venus Williams advanced to the third round with a straight-set victory earlier Wednesday.
Serena leads Venus 17-12 overall and 15-10 at majors.
Other significant results today:
John Isner reached the US Open's third round for the seventh consecutive year, hitting 38 aces to come back and edge 42nd-ranked Nicolas Jarry of Chile 6-7 (7), 6-4, 3-6, 7-6 (2), 6-4.
The 11th-seeded Isner is the highest-ranked American man in New York for the seventh time in a row, but he's only once made it to the fourth round in that span.
He broke Jarry for the second and last time at 4-all in the fifth set, flicking a backhand lob winner to take that game.
After serving out the win, Isner walked over and slapped palms with front-row spectators
Andy Murray's return to the US Open lasted just two rounds.
The 2012 champion was eliminated by No. 31 seed Fernando Verdasco 7-5, 2-6, 6-4, 6-4.
The Spaniard will face a second straight past champion at Flushing Meadows when he meets third-seeded Juan Martin del Potro in the third round.
Murray missed last year's tournament because of a hip injury and didn't consider himself a contender this year because of his lack of preparation.
Verdasco won for just the second time in 15 career meetings with Murray, who had multiple chances to even the final game of a 64-minute final set before the left-hander finished it.
Juan Martin del Potro moved on to what could be a third-round matchup of past US Open champions by beating American Denis Kudla 6-3, 6-1, 7-6 (4).
The No. 3 seed from Argentina was the 2009 champion.
Venus Williams earlier did her part to set up the all-Williams showdown.
The 16th-seeded Williams reached the third round at Flushing Meadows for the fifth year in a row, beating 40th-ranked Camila Giorgi of Italy 6-4, 7-5 despite producing fewer than half as many winners.
Of the 82 points that went her way today, only 13 came via her own winners.
Giorgi had 29 winners, but also 41 unforced errors and 28 forced errors.
Defending champion Sloane Stephens rallied to reach the third round with a 4-6, 7-5, 6-2 victory over Anhelina Kalinina.
Stephens set up a third-round matchup with Victoria Azarenka, the former No. 1 player who has twice been a US Open finalist.
Stephens served an ace to finally put away the 2-hour, 46-minute match against Kalinina, a Ukrainian qualifier who was playing her first Grand Slam tournament.
Stan Wawrinka ran his US Open winning streak to nine with a 7-6 (5), 4-6, 6-3, 7-5 victory over qualifier Ugo Humbert of France.
Wawrinka, the 2016 champion who missed the Grand Slam tournament last year because of two left knee surgeries, advances to face No. 25 seed Milos Raonic of Canada in the third round.
Raonic swept past Gilles Simon of France 6-3, 6-4, 6-4.
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